7khh(iihfwwrii7*)doskddrqq1hxurjhqhvlvvlqq6xeyhqwulfxodu =rqhhrii5dww%udlqqdiwhu,vfkhpld5hshuixvlrq

* Corresponding Author: Mehdi Mehdizadeh, PhD. Anatomical Sciences Department of Anatomical Sciences, Cellular and Molecular Research Center, Tehran University of Medical Sciences, Tehran , Iran. PO Box:15875-1454. Tel/Fax: +98(21)88622689 E-mail: [email protected] Introduction: Stroke is the third important reason of death in adults and an important cause of adult disability. Previous studies suggest that TGF-alpha can induce neurogenesis after stroke. Here in, we studied neurogenesis effects of the TGF-alpha on subventricular zone following ischemia-reperfusion. Methods: Male wistar rats (250-300 g) were divided into ischemia and treatment groups. After induction of ischemia-reperfusions, PBS (phosphate buffer salin) and TGF-alpha 50 ng were injected stereotaxicaly in lateral ventricle in ischemia and treatment respectively. After 12 days, the nestin expression in subventricular zone was assessed by immunohistochemical staining method. Results: & " # treatment group in comparison with ischemia group (p<0.05). Discussion: " >“› <€^X œ $ neural stem cells proliferation after ischemia – reperfusion injury. A B S T R A C T Article info: Received: 5 October 2011 First Revision: 10 November 2011 Accepted: 25 December 2011